SMZ25 Research Stereo Microscope

by Nikon

Nikon's SMZ25 research stereomicroscope combines macro and micro imaging in one instrument for convenient viewing and manipulation of single cells to whole organisms. Using Nikon's Perfect Zoom System optical technology, the SMZ25 achieves the world's first 25:1 zoom and high NA for superior resolution never before seen with a stereomicroscope.

Using these innovative optics and a fly-eye lens, crystal clear fluorescent images with improved S/N ratios are possible, even in low-excitation light applications such as cell division. Additionally, even at low magnifications, the SMZ25 has a 35mm F.O.V, allowing users to capture an entire 35mm dish with uniform brightness.

All-new "Perfect Zoom System" Offers New Levels of Imaging Power and Versatility

A breakthrough in stereomicroscope design, the SMZ25's Perfect Zoom System dynamically changes the distance between the two optical axes as the zoom factor varies. This change in optical axis distance enables maximization of light entry into the optical system at every magnification. The result is a large zoom range, high resolution in both eye-paths, and minimal aberrations over the entire zoom range

World's Largest Zoom Range Enables High Resolution Macro to Micro Imaging

Nikon's exclusive Perfect Zoom System provides the world's first zoom ratio of 25:1 (zoom range: 0.63x - 15.75x*). Even with a 1x objective lens, the SMZ25 captures the entire 35mm dish and simultaneously delivers microscopic details

Auto Link Zoom (ALZ) Provides Seamless Viewing at Different Magnifications

The SMZ25's exclusive Auto Link Zoom (ALZ) automatically adjusts the zoom factor to maintain the same field of view when switching objective lenses. This function enables seamless switching between whole organism imaging at low magnifications and detailed imaging at high magnifications

Brighter and Higher Contrast Epi-fluorescence Imaging

Even at low magnification, the SMZ25 captures an entire 35mm dish with equal brightness over the whole field of view, making it ideal for live screening of developmental models such as C. elegans, Drosophila, zebrafish, and mice to identify and select mutants.

The SMZ25 also allows brilliant images to be captured even with low excitation light levels, minimizing photo-bleaching and photo-toxicity which is harmful to live cells and organisms.

The SMZ25 combines fly-eye technology, which uniformly illuminates the entire field of view, and a high S/N ratio along with increased transmission for incredibly bright fluorescence, even at low magnifications. This also minimizes photobleaching and phototoxicity, thus reducing harm to live cells and organisms

Improved Signal-to-Noise Ratios

Nikon's newly developed optical system offers a drastic improvement in S/N ratio even at high magnifications. The improved S/N ratio makes it possible to capture cell division, which is difficult using conventional stereomicroscopes, and samples with low excitation light

On-axis imaging for digital images

Easily switch between stereo position (stereoscopic view) and mono position (on-axis view) when using the P2-RNI2 Intelligent Nosepiece by simply sliding the objective lens. Digital images with uncompromised clarity can be captured using the mono position

User-Friendly Controller

The all-new controller provides easy access to zoom and focus controls and is designed for both right- and left-hand use. The remote controller contains an LCD monitor with an adjustable backlight which provides information regarding the zoom factor, objective lens, filter cube, and LED DIA brightness at a glance. The backlight on the LCD monitor can also be turned off to eliminate interference with low-light imaging applications. In addition to the remote controller, the microscope can also be operated through a PC

NIS-Elements Imaging Software

Nikon's flagship, cross-platform imaging, software can now be used with Nikon's newest stereomicroscope systems. NIS-Elements enables a wide range of advanced digital imaging capabilities, easily from a PC

Digital Sight DS-L3 Digital Camera System

The DS-L3 is an easy-to-use high-definition, large touch-panel monitor that can be used to quickly capture images without a PC

Fiber DIA Base

Fiber DIA base features condenser lenses that can be switched between low and high magnifications. Furthermore, the Oblique Coherent Contrast (OCC) illumination system allows high contrast illumination

Slim Bases

The slimmer LED DIA Base and Plain Base help increase efficiency of sample manipulation by bringing the level of the sample closer to the table


Choose from two types of tilting trinocular tube and one type of low eyelevel trinocular tube. All tubes have a camera port for seamless integration with the Digital Sight series

Nosepiece / Focus Mount Adapter

There is one type of nosepiece that can mount two objective lenses and two types of focus mount adapters for use with a single objective lens


The stage features an XY stroke of 6x4 inches (150mm x 100mm) and can be attached to any of the bases, making it effective for capturing large images when used in combination with the imaging software NIS-Elements. A sliding stage and tilting stage are also available


Nikon offers a remote control unit that can be used to operate the microscope and capture images by hand. A footswitch is also offered, allowing the user to operate the microscope and capture images by foot, freeing the hands for sample manipulation

Motorized Epi-fluorescence Light Set

The fluorescent turret can be operated using the remote control or imaging software NIS-Elements

Manual Epi-fluorescence Light Set

An easy-to-use manual model for Nikon's newly developed high performance epi-fluorescence attachment

Flexible Double Arm Fiber Illumination Set

The direction and angle of illumination can be changed to suit the sample by making adjustments with these double arms. The fiber holder position can also be changed to obtain the optimal position for illuminating samples

Manual Epi-Fluorescence Light Set

Coaxial Illuminator: The coaxial light illuminator makes it possible to view light reflected from the surface of a sample, which is ideal for shooting shadow-less images of thick samples

Ring LED Illuminator

This ring fiber illumination set features an episcopic illumination unit that effectively captures images (can be used with 1x and 0.5x objective lenses)

Darkfield Observation Accessory

Darkfield viewing is possible simply by attaching the darkfield unit to the base

Polarizing Observation Accessory

The analyzer is attached to the objective and the polarizer to the base or stand to enable polarized viewing

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